Patients are most commonly prescribed biguanides (eg, metformin), historically followed by insulin secretagogues such as sulfonylureas (eg, glipizide) and meglitinides (eg, repaglinide). The majority of patients with T2D are on some form of oral antidiabetic agent. It is important that clinicians be aware of some of the most common interactions with T2D medications and not rely solely on electronic software to flag such interactions. However, although this software helps to monitor for interactions, it can be fallible. Most clinicians use electronic medical software that will alert when such interactions are present. 1For that reason, a complete drug and supplement inventory must be part of the patient intake process at each visit. It is alarming that fewer than 40% of patients reveal their use of dietary supplements to their health care provider, when an estimated 20% to 30% of people on prescription medicine take some form of botanical supplement. When treating these patients for acute and chronic illnesses beyond their T2D diagnosis, clinicians should inquire about any dietary supplements and medications they may be taking. ![]() ![]() It is important to be aware of drug-drug and drug–supplement interactions with these patients. Type 2 diabetes (T2D) is an unfortunate reality for many patients who are seen in primary care settings on a regular basis.
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